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CAL-101 (GS-1101)

A potent PI3K p110δ inhibitor
Catalog #: 2613
SKU-Size Size Price Qty
2613-5 5 mg
2613-25 25 mg
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Product Details

Alternate Name 5-​fluoro-​3-​phenyl-​2-​[(1S)-​1-​(9H-​purin-​6-​ylamino)propyl]-​4(3H)-​quinazolinone; Idelalisib
Appearance White solid
CAS # 870281-82-6
Molecular Formula C₂₂H₁₈FN₇O
Molecular Weight 415.42
Purity >98% by HPLC
Solubility DMSO(~ 25 mg/ml) or EtOH (~ 15 mg/ml)
InChi InChI=1S/C22H18FN7O/c1-2-15(28-20-18-19(25-11-24-18)26-12-27-20)21-29-16-10-6-9-14(23)17(16)22(31)30(21)13-7-4-3-5-8-13/h3-12,15H,2H2,1H3,(H2,24,25,26,27,28)/t15-/m0/s1
PubChem CID 11625818
Handling Protect from air and light
Storage Conditions -20 ̊C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


CAL-101 is a cell-permeable inhibitor of the PI3K catalytic subunit p110δ (IC₅₀ = 2.5 nM) that displays 40- to 300-fold selectivity against other PI3K class I enzymes (IC₅₀s = 820, 565, and 89 nM for p110α, β, and γ, respectively). It has also been shown to inhibit the chemotaxis of chronic lymphocytic leukemia cells and to downregulate the secretion of chemokines triggered by B-cell receptor signaling.

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