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Cadherin-6 (Human) ELISA Kit

A highly sensitive sandwich ELISA kit for the quantitative measurement of Cadherin-6

WARNING: This product can expose you to chemicals including Sulfuric acid and TMB, which are known to the State of California to cause cancer. For more information go to www.P65Warnings.ca.gov.
Catalog #: E5125
$750.00

Product Details

Cat # +Size E5125-100
Size 96 assays
Detection Method Absorbance is measured at 450 nm
Species Reactivity Human
Applications The ELISA kit is used for the quantitative detection of Cadherin-6 in serum, plasma, tissue homogenates and other biological fluids
Features & Benefits ● Highly sensitive and specific
● Recovery Rate: 86-103% for serum, 95-104% for EDTA plasma and 97-99% for heparin plasma
● Sensitivity: 0.188 ng/ml
● Assay Precision; Intra-Assay CV < 8% and Inter-Assay < 10%
● Detection range: 0.313-20 ng/ml
Kit Components ● ELISA Microplate
● Wash Buffer (25X)
● Plate Sealers
● Lyophilized Standard (20 ng)
● Sample/Standard Dilution Buffer
● Biotin-labeled Antibody (Concentrated)
● Antibody Dilution Buffer
● HRP-Streptavidin Conjugate (SABC)
● SABC Dilution Buffer
● TMB Substrate
● Stop Solution
Storage Conditions 4ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Cadherins are a family of calcium-dependent, cell-cell adhesion molecules that play an important morpho regulatory role in a wide variety of tissues. Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Cadherins are not just structural proteins, but they act as sensors of the surrounding microenvironment and as signaling centers for cellular pathways. Cadherin-6 (CDH6) is a type 2 cadherin, which drives EMT during embryonic development and it is aberrantly re-activated in cancer. Cadherin-6 function is required for the early aggregation of induced mesenchymal cells and their subsequent conversion to epithelium. Diseases associated with Cadherin-6 include Craniofacial-Deafness-Hand Syndrome and Renal Cell Carcinoma. The alterations of cadherin-6 expression are associated with progression of renal cell carcinoma. BioVision’s Cadherin-6 (Human) ELISA Kit is used for the quantitative detection of Cadherin-6 in serum, plasma, tissue homogenates and other biological fluids. It is based on the principle of sandwich ELISA. The capture antibody is pre-coated on 96-well plates. The standards, test samples and biotin conjugated detection antibody are added to the wells subsequently, and washed with wash buffer. HRP-Streptavidin is added and unbound conjugates are washed away with wash buffer. The HRP enzymatic reaction is detected using TMB-substrate. Finally, an acidic stop solution terminates the enzymatic reaction. The color developed is directly proportional to the amount of Cadherin-6 in the sample.


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