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CA19-9 Antibody (Clone# 121SLE), Carrier-Free

BSA and Azide-free mouse monoclonal antibody to detect CA19-9 in human samples
Catalog #: A2227
$425.00

Product Details

Cat # +Size A2227-100
Size 100 μg
Antibody Target CA19-9
Alternate Name Pancreatic tumor antigen, Ovarian tumor antigen, Sialyl Lewisa, CA19.9
Host Mouse
Antibody Type Monoclonal
Isotype IgM, kappa
Immunogen Precipitin lines obtained after immuno-diffusion using MAb 116-NS-19-9 and mucins isolated from an ovarian cyst of a Lewis A+B- patient
Appearance Colorless liquid
Concentration 1 mg/ml
Formulation In 10 mM PBS
Purification Protein A/G purification
Species Reactivity Human
Application Immunohistochemistry (IHC)
Application & Usage IHC 1-2 µg/ml
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

CA19-9, a carbohydrate epitope expressed on a high MW (400 kDa) mucin glycoprotein, is a sialyl Lewisa structure that is synthesized from type 1 blood group precursor chains and is present in individuals expressing the Lewisa and/or Lewisb blood group antigens. In normal tissues, sialyl Lewisa antigen is present in the ductal epithelium of the breast, kidney, salivary gland, and sweat glands. Its expression is greatly enhanced in serum as well as in the majority of tumor cells in gastrointestinal (GI) carcinomas, including adenocarcinomas of the stomach, intestine, and pancreas. Preoperative elevated CA19-9 levels in patients with stage I pancreatic carcinoma decrease to normal values following surgery. When used serially, CA19-9 can predict the recurrence of disease before radiographic or clinical findings. This BSA and Azide-free monoclonal antibody are excellent for staining of formalin-fixed, paraffin-embedded tissues.


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