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CA-074

An inhibitor of cathepsin B
Catalog #: B2971
SKU-Size Size Price Qty
B2971-1 1 mg
$145.00
B2971-5 5 mg
$580.00
More Sizes Get Quote

Product Details

Alternate Name (2S)-1-[(2S,3S)-3-methyl-2-[[(2S,3S)-3-(propylcarbamoyl)oxirane-2-carbonyl]amino]pentanoyl]pyrrolidine-2-carboxylic acid; Cathepsin B Inhibitor III; N-{[(2S,3S)-3-(propylcarbamoyl)oxiran-2-yl]carbonyl}-L-isoleucyl-L-proline
Appearance White powder
CAS # 134448-10-5
Molecular Formula C₁₈H₂₉N₃O₆
Molecular Weight 383.44
Purity 98%
Solubility ~8 mg/ml in DMSO
SMILES CCCNC(=O)C1C(O1)C(=O)NC(C(C)CC)C(=O)N2CCCC2C(=O)O
InChi InChI=1S/C18H29N3O6/c1-4-8-19-15(22)13-14(27-13)16(23)20-12(10(3)5-2)17(24)21-9-6-7-11(21)18(25)26/h10-14H,4-9H2,1-3H3,(H,19,22)(H,20,23)(H,25,26)/t10-,11-,12-,13-,14-/m0/s1
InChi Key ZEZGJKSEBRELAS-PEDHHIEDSA-N
PubChem CID 9821383
MDL Number MFCD00797531
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.

Details

CA-074 is an epoxysuccinyl peptide inhibitor of cathepsin B. It selectively inhibits cathepsin B with an IC₅₀ of 2.24 nM over other cysteine proteinases such as cathepsins L and H, and calpains. It inhibits cathepsins H, L and calpain with IC₅₀ values of 172 μM, 420 μM and 200 μM. Intraperitoneal administration (50 mg/kg) of CA-074 reduces metastasis in 4T1.2 mouse xenograft model. It reduces mercury induced expression of inflammatory cytokines in mice.


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