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An inhibitor of Tumor Necrosis Factor α
Catalog #: B3062
SKU-Size Size Price Qty
B3062-5 5 mg
B3062-25 25 mg
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Product Details

Alternate Name 4-[(4-chloro-3-nitrophenyl)diazenyl]-5-phenyl-2-(4-phenyl-1,3-thiazol-2-yl)-1H-pyrazol-3-one; 3-phenyl-1-(4-phenyl-1,3-thiazol-2-yl)-1H-pyrazole-4,5-dione 4-({4-chloro-3-nitrophenyl}hydrazone); 4-[(E)-2-(4-chloro-3-nitrophenyl)hydrazono]-5-phenyl-2-(4-phenyl-1,3-thiazol-2-yl)-2,4-dihydro-3H-pyrazol-3-one; TNF-TNFR Signaling Inhibitor IV
Appearance Orange Red Solid
CAS # 332420-90-3
Molecular Formula C₂₄H₁₅ClN₆O₃S
Molecular Weight 502.93
Purity ≥98%
Solubility 5 mg/ml in DMSO
SMILES C1=CC=C(C=C1)C2=CSC(=N2)N3C(=O)C(=C(N3)C4=CC=CC=C4)N=NC5=CC(=C(C=C5)Cl)[N+](=O)[O-]
InChi InChI=1S/C24H15ClN6O3S/c25-18-12-11-17(13-20(18)31(33)34)27-28-22-21(16-9-5-2-6-10-16)29-30(23(22)32)24-26-19(14-35-24)15-7-3-1-4-8-15/h1-14,29H
PubChem CID 4016403
MDL Number MFCD00810005
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.


C87 is an inhibitor of Tumor Necrosis Factor α (TNFα). It binds to human TNFα with a KD of 110 nM and potently inhibits TNFα-induced cytotoxicity in L929 cells with an IC₅₀ of 8.73 μM. It effectively blocks TNFα-triggered signaling pathways and attenuates TNFα-induced inflammation in a mouse model of hepatitis.

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