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C646, p300/CBP Inhibitor

based on 1 citations in multiple journalsC646, p300/CBP Inhibitor14.1 4
A reversible, p300/CBP (CREB-binding protein) histone acetyltransferase (HAT) inhibitor
Catalog #: 1948
SKU-Size Size Price Qty
1948-1 1 mg
$90.00
1948-5 5 mg
$355.00
More Sizes Get Quote

Product Details

Alternate Name (E)-4-(4-((5-(4,5-Dimethyl-2-nitrophenyl)furan-2-yl)-methylene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid
Appearance Red solid
CAS # 328968-36-1
Molecular Formula C₂₄H₁₉N₃O₆
Molecular Weight 445.42
Purity ≥98% by NMR
Solubility DMSO (25 mM)
SMILES CC1=C(C=C(C(=C1)C2=CC=C(O2)C=C3C(=NN(C3=O)C4=CC=C(C=C4)C(=O)O)C)[N+](=O)[O-])C
InChi InChI=1S/C24H19N3O6/c1-13-10-20(21(27(31)32)11-14(13)2)22-9-8-18(33-22)12-19-15(3)25-26(23(19)28)17-6-4-16(5-7-17)24(29)30/h4-12H,1-3H3,(H,29,30)/b19-12-
InChi Key HEKJYZZSCQBJGB-UNOMPAQXSA-N
PubChem CID 1285941
MDL Number MFCD01784780
Handling Protect from light and air
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Cell-permeable. A reversible, p300/CBP (CREB-binding protein) histone acetyltransferase (HAT) inhibitor (Ki = 400 nM). Specific inhibition to p300 (86%) compared to N-acetyltransferase, PCAF, GCN5, Rtt109, Sas or MOZ histone acetyltransferases (<10%). Suppresses histone H3 and H4 acetylation in mouse fibroblast cell lines.


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Chen et al., SREBP-1 is a novel mediator of TGFβ1 signaling in mesangial cells. J Mol Cell Biol, Dec 2014; 6: 516 - 530.
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