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C5a (His-Tag), murine recombinant

An anaphylatoxin
Catalog #: 4895A
SKU-Size Size Price Qty
4895A-20 20 μg
$215.00
4895A-100 100 μg
$655.00
4895A-1000 1 mg
$4,950.00
More Sizes Get Quote

Product Details

Alternate Name Complement Fragments C5a, C5a anaphylatoxin chemotactic receptor
Gene Symbol C5a
Gene ID 15139
Accession # NP_034536
Source E. coli
Appearance Lyophilized protein
Physical Form Description Sterile filtered and lyophilized with no additives
Molecular Weight 9 kDa
Purity by SDS-PAGE ≥95%
Endotoxin Level <0.1 ng/μg
Biological Activity ED₅₀ 1-3 nM as determined by enzyme release assay of myeloperoxidase
Reconstitution Instructions Reconstitute to a concentration of 1.0 mg/ml in ice-cold H₂O containing 2.5 mg/ml BSA. The solution should be aliquoted and immediately stored at -70°C.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
USAGE For Research Use Only! Not to be used in humans

Details

Mouse complement C5a is a 77-amino acid peptide generated during complement activation from the α-chain of complement C5. Mouse C5a shares 60% and 82% amino acid sequence identity to human and rat C5a, respectively. C5a binds to a signaling G-protein coupled receptor (GPCR) (C5aR/CD88), inducing neutrophil chemotaxis and endothelial cell activation. It also triggers an oxidative burst in macrophages and neutrophils, and induces release of histamine in basophils and mast cells. The 9 kDa mouse C5a protein expressed in E. coli contains a N-terminal His-Tag sequence.


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Jun, H. S. et. al. G-CSF improves murine G6PC3-deficient neutrophil function by modulating apoptosis and energy homeostasis. Blood, Apr 2011; 117: 3881 - 3892. 
Tole, S. et al. The Axonal Repellent, Slit2, Inhibits Directional Migration of Circulating Neutrophils. J. Leukoc. Biol. 2009; 86: 1403-1415.
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