Product Details
| abID | ab285676 |
|---|---|
| Alternate Name | Complement Fragments C5a, C5a anaphylatoxin chemotactic receptor |
| Gene Symbol | C5a |
| Gene ID | 15139 |
| Accession # | NP_034536 |
| Source | E. coli |
| Appearance | Lyophilized protein |
| Physical Form Description | Sterile filtered and lyophilized with no additives |
| Molecular Weight | 9 kDa |
| Purity by SDS-PAGE | ≥95% |
| Endotoxin Level | <0.1 ng/μg |
| Biological Activity | ED₅₀ 1-3 nM as determined by enzyme release assay of myeloperoxidase |
| Reconstitution Instructions | Reconstitute to a concentration of 1.0 mg/ml in ice-cold H₂O containing 2.5 mg/ml BSA. The solution should be aliquoted and immediately stored at -70°C. |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -20°C |
| USAGE | For Research Use Only! Not to be used in humans |
Details
Mouse complement C5a is a 77-amino acid peptide generated during complement activation from the α-chain of complement C5. Mouse C5a shares 60% and 82% amino acid sequence identity to human and rat C5a, respectively. C5a binds to a signaling G-protein coupled receptor (GPCR) (C5aR/CD88), inducing neutrophil chemotaxis and endothelial cell activation. It also triggers an oxidative burst in macrophages and neutrophils, and induces release of histamine in basophils and mast cells. The 9 kDa mouse C5a protein expressed in E. coli contains a N-terminal His-Tag sequence.
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Faith H. Brennan. Complement receptor C3aR1 controls neutrophil mobilization following spinal cord injury through physiological antagonism of CXCR2. JCI Insight May-19. 31045582.
Jun, H. S. et. al. G-CSF improves murine G6PC3-deficient neutrophil function by modulating apoptosis and energy homeostasis. Blood, Apr 2011; 117: 3881 - 3892.
Tole, S. et al. The Axonal Repellent, Slit2, Inhibits Directional Migration of Circulating Neutrophils. J. Leukoc. Biol. 2009; 86: 1403-1415.
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