C5a (His-Tag), murine recombinant

An anaphylatoxin
Catalog #: 4895A | abID: ab285676

Product Details

abID ab285676
Alternate Name Complement Fragments C5a, C5a anaphylatoxin chemotactic receptor
Gene Symbol C5a
Gene ID 15139
Accession # NP_034536
Source E. coli
Appearance Lyophilized protein
Physical Form Description Sterile filtered and lyophilized with no additives
Molecular Weight 9 kDa
Purity by SDS-PAGE ≥95%
Endotoxin Level <0.1 ng/μg
Biological Activity ED₅₀ 1-3 nM as determined by enzyme release assay of myeloperoxidase
Reconstitution Instructions Reconstitute to a concentration of 1.0 mg/ml in ice-cold H₂O containing 2.5 mg/ml BSA. The solution should be aliquoted and immediately stored at -70°C.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
USAGE For Research Use Only! Not to be used in humans


Mouse complement C5a is a 77-amino acid peptide generated during complement activation from the α-chain of complement C5. Mouse C5a shares 60% and 82% amino acid sequence identity to human and rat C5a, respectively. C5a binds to a signaling G-protein coupled receptor (GPCR) (C5aR/CD88), inducing neutrophil chemotaxis and endothelial cell activation. It also triggers an oxidative burst in macrophages and neutrophils, and induces release of histamine in basophils and mast cells. The 9 kDa mouse C5a protein expressed in E. coli contains a N-terminal His-Tag sequence.

Why buy BioVision Products?
Global Presence
Technical Support
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways.
BioVision is committed to providing the highest quality products at a competitive price.
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery.
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently.
Faith H. Brennan. Complement receptor C3aR1 controls neutrophil mobilization following spinal cord injury through physiological antagonism of CXCR2. JCI Insight May-19. 31045582.
Jun, H. S. et. al. G-CSF improves murine G6PC3-deficient neutrophil function by modulating apoptosis and energy homeostasis. Blood, Apr 2011; 117: 3881 - 3892. 
Tole, S. et al. The Axonal Repellent, Slit2, Inhibits Directional Migration of Circulating Neutrophils. J. Leukoc. Biol. 2009; 86: 1403-1415.
For more citations of this product click here