Product Details
abID | ab283366 |
---|---|
Cat # +Size | K2015-100 |
Size | 100 assays |
Kit Summary | BioVision’s c-Src Kinase Inhibitor Screening Kit enables rapid screening of test compounds for modulation of c-Src activity. The assay uses a c-Src-specific polypeptide substrate and a high concentration of the ultra-pure ATP that closely reflects the physiological ATP levels. ADP formation during the kinase reaction is measured. The strong and stable fluorescence signal (Ex/Em = 535/587 nm) generated during the reaction is directly proportional to the amount of ADP generated. This ensures a high signal-to-background ratio and a little interference due to short wavelength fluorescence by test compounds. The assay is simple, highly sensitive and is high-throughput adaptable. The kit contains a complete set of reagents sufficient for performing 100 reactions in a 96-well plate format. |
Detection Method | Fluorescence (Ex/Em = 535/587 nm) |
Species Reactivity | Mammalian |
Applications | • Screening and characterization of drugs and novel chemical entities for inhibition or modulation of c-Src activity. • Development of structure-activity relationship models to predict Src kinase selectivity of compounds. |
Features & Benefits | • Simple • Rapid screening of test compounds for modulation of c-Src activity • High-throughput adaptable • Highly sensitive |
Kit Components | Src Peptide Substrate Developer Enzyme Mix Src Assay Buffer Fluorogenic Probe Dasatinib (1 mM) Recombinant Human c-Src Ultra-Pure ATP ADP Detection Mix |
Storage Conditions | -80°C |
Shipping Conditions | Dry Ice |
USAGE | For Research Use Only! Not For Use in Humans. |
Details
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