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C-Myc Antibody

Polyclonal Antibody to detect c-Myc in human samples. Predicted reactivity with Mouse, Rat, Bovine and Pig samples also.
Catalog #: 6767
$245.00

Product Details

Cat # +Size 6767-100
Size 100 μl
Antibody Target C-Myc
Alternate Name MYC; BHLHE39; Myc proto-oncogene protein; Class E basic helix-loop-helix protein 39; Proto-oncogene c-Myc; Transcription factor p64
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen This MYC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 40-69 amino acids from human MYC.
Accession # 4609
Gene ID P01106
Appearance Colorless liquid
Formulation Supplied in in PBS with 0.09% (W/V) sodium azide.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Species Reactivity Human. Predicted reactivity with Mouse, Rat, Bovine and Pig samples.
Application Western blot, FACS.
Positive Control Western blot: 293 cell lysate, FACS: 293 cells
Application & Usage Western blot: ~1:1000, FC: 1:10 – 1:50.
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

c-Myc-, N-Myc- and L-Myc-encoded proteins function in cell proliferation, differentiation and neoplastic disease. Myc proteins are nuclear proteins with relatively short half-lives. Amplification of the c-Myc gene has been found in several types of human tumors including lung, breast and colon carcinomas, while the N-Myc gene has been found amplified in neuroblastoma. The L-Myc gene has been reported to be amplified and expressed at high level in human small cell lung carcinomas. The presence of three sequence motifs in the c-Myc COOH terminus, including the leucine zipper, the helix-loop-helix and a basic region provided initial evidence for a sequence-specific binding function. A basic region helix-loop-helix leucine zipper motif (bHLH-Zip) protein designated Max, specifically associates with c-Myc, N-Myc and L-Myc proteins. The Myc-Max complex binds to DNA in a sequence-specific manner under conditions where neither Max nor Myc exhibit appreciable binding. Max can also form heterodimers with at least two additional bHLH-Zip proteins, Mad and Mxi1, and Mad-Max dimers have been shown to repress transcription through interaction with mSin3.


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