Product Details
| Antibody Target | c-Jun |
|---|---|
| Alternate Name | JUN , AP1 , p39 , c-Jun |
| Host | Rabbit |
| Antibody Type | Polyclonal |
| Isotype | Rabbit IgG |
| Immunogen | E. coli-expressed recombinant human c-Jun fusion protein |
| Accession # | P05412 |
| Gene ID | 3725 |
| Appearance | Colorless liquid |
| Concentration | 0.5 mg/ml |
| Formulation | In phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 5 mM EDTA and 0.03% proclin. |
| Purification | Affinity purified |
| Species Reactivity | Human |
| Application | Western blot |
| Positive Control | Recombinant human c-Jun (Cat.# 7001-100) |
| Application & Usage | The antibody can be used in Western Blot analysis (0.5-4 µg/ml). However, the optimal conditions should be determined individually. Recombinant human c-Jun (Cat.# 7001-100) can be used as a positive control. |
| Handling | The antibody solution should be gently mixed before use. |
| Storage Conditions | -20 °C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
c-Jun is a component of the transcription factor AP-1 that binds and activates transcription at TRE/AP-1 elements. The transcriptional activity of c-Jun is regulated by phosphorylation at Ser63 and Ser73. Extracellular signals including growth factors, transforming oncoproteins, and UV irradiation stimulate phosphorylation of c-Jun at Ser63/73 and activate c-Jun dependent transcription. The MAP kinase homologue, JNK, binds to the N-terminal region of c-Jun and phosphorylates c-Jun at Ser63/73. The activity of JNK is stimulated by the same signals that activate c-Jun.
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