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c-Jun (1-79)-GST Fusion Protein

based on 1 citations in multiple journalsc-Jun (1-79)-GST Fusion Protein14.1 4
Plays a role in cell proliferation and apoptosis
Catalog #: 7001
$145.00

Product Details

Cat # +Size 7001-100
Size 100 μg
Alternate Name Transcription factor AP-1, (Activator protein 1) (AP1) (Proto-oncogene c-Jun) (V-jun avian sarcoma virus 17 oncogene homolog) (p39)
Gene Symbol JUN; AP1; c-Jun
Gene ID 3725
Accession # P05412
Source E. coli
Appearance Liquid
Physical Form Description 2 mg/ml in storage buffer containing 20 mM Tris-HCl (pH 7.5), 50 mM NaCl, 2 mM EDTA, 1 mM DTT, and 50% glycerol.
Molecular Weight 37.0 kDa
Purity by SDS-PAGE ≥90%
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

c-Jun is a component of the transcription factor AP-1 that binds and activates transcription at TRE/AP-1 elements. The transcriptional activity of c-Jun is regulated by phosphorylation at Ser63 and Ser73. Extracellular signals including growth factors, transforming oncoproteins, and UV irradiation stimulate phosphorylation of c-Jun at Ser63/73 and activate c-Jun dependent transcription. The MAP kinase homologue, JNK, binds to the N-terminal region of c-Jun and phosphorylates c-Jun at Ser63/73. The activity of JNK is stimulated by the same signals that activates c-Jun.


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Michaelis, M. L. et al. (2005) J. Pharmacol. Exp. Ther. 312: 659-668.
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