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Product Details
| Cat # +Size | 7001-100 |
|---|---|
| Size | 100 μg |
| Alternate Name | Transcription factor AP-1, (Activator protein 1) (AP1) (Proto-oncogene c-Jun) (V-jun avian sarcoma virus 17 oncogene homolog) (p39) |
| Gene Symbol | JUN; AP1; c-Jun |
| Gene ID | 3725 |
| Accession # | P05412 |
| Source | E. coli |
| Appearance | Liquid |
| Physical Form Description | 2 mg/ml in storage buffer containing 20 mM Tris-HCl (pH 7.5), 50 mM NaCl, 2 mM EDTA, 1 mM DTT, and 50% glycerol. |
| Molecular Weight | 37.0 kDa |
| Purity by SDS-PAGE | ≥90% |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not to be used in humans |
Details
c-Jun is a component of the transcription factor AP-1 that binds and activates transcription at TRE/AP-1 elements. The transcriptional activity of c-Jun is regulated by phosphorylation at Ser63 and Ser73. Extracellular signals including growth factors, transforming oncoproteins, and UV irradiation stimulate phosphorylation of c-Jun at Ser63/73 and activate c-Jun dependent transcription. The MAP kinase homologue, JNK, binds to the N-terminal region of c-Jun and phosphorylates c-Jun at Ser63/73. The activity of JNK is stimulated by the same signals that activates c-Jun.
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Michaelis, M. L. et al. (2005) J. Pharmacol. Exp. Ther. 312: 659-668.
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