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BX-912

A potent and selective inhibitor of PDK1
Catalog #: B1765

In stock

SKU-Size Size Price Qty
B1765-5 5 mg
$135.00
B1765-25 25 mg
$535.00
More Sizes Get Quote

Product Details

Alternate Name BX-912; BX 912; BX912; N-[3-[[5-bromo-4-[2-(1H-imidazol-5-yl)ethylamino]pyrimidin-2-yl]amino]phenyl]pyrrolidine-1-carboxamide; N-(3-((4-((2-(1H-imidazol-4-yl)ethyl)amino)-5-bromopyrimidin-2-yl)amino)phenyl)pyrrolidine-1-carboxamide; PDK1 inhibitor
Appearance Solid
CAS # 702674-56-4
Molecular Formula C₂₀H₂₃BrN₈O
Molecular Weight 471.35
Purity >98%
Solubility DMSO
SMILES C1CCN(C1)C(=O)NC2=CC=CC(=C2)NC3=NC=C(C(=N3)NCCC4=CN=CN4)Br
InChi InChI=1S/C20H23BrN8O/c21-17-12-24-19(28-18(17)23-7-6-16-11-22-13-25-16)26-14-4-3-5-15(10-14)27-20(30)29-8-1-2-9-29/h3-5,10-13H,1-2,6-9H2,(H,22,25)(H,27,30)(H2,23,24,26,28)
InChi Key DMMILYKXNCVKOJ-UHFFFAOYSA-N
PubChem CID 11754511
MDL Number MFCD10565925
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

BX-912 is a potent and selective inhibitor of 3-phosphoinositide-dependent kinase 1 (PDK1) with IC50 value of 26nM. BX-912 has shown 9-fold selectivity for PDK1 relative to PKA and 105-fold selectivity against PKC.


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