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Butyrolactone I

A CDK inhibitor
Catalog #: 1690
$130.00

Product Details

Cat # +Size 1690-200
Size 200 µg
Alternate Name BLI, BL-I
Appearance White solid
CAS # 87414-49-1
Molecular Formula C₂₄H₂₄O₇
Molecular Weight 424.44
Purity ≥99% by HPLC
Solubility DMSO (10 mg/ml) and Ethanol (25 mg/ml)
SMILES CC(=CCC1=C(C=CC(=C1)COC(=O)C2(C(=C(C(=O)O2)O)C3=CC=C(C=C3)O)C)O)C
InChi InChI=1S/C24H24O7/c1-14(2)4-6-17-12-15(5-11-19(17)26)13-30-23(29)24(3)20(21(27)22(28)31-24)16-7-9-18(25)10-8-16/h4-5,7-12,25-27H,6,13H2,1-3H3/t24-/m1/s1
InChi Key FPVUCBMBMUHRDX-XMMPIXPASA-N
PubChem CID 3035414
MDL Number MFCD03453074
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Cell permeable. A potent and selective inhibitor of the cyclin-dependent kinases CDK1/cyclin B, CDK2 and CDK5. Inhibits cell cycle progression at the G1/S and G2/M transitions. BLI is an important tool for probing the cellular roles of CDKs. It blocks Fas-induced apoptosis and displays antitumor activity.


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