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Butyrolactone 3

An inhibitor of histone acetyltransferase Gcn5
Catalog #: B2817
SKU-Size Size Price Qty
B2817-1 1 mg
$75.00
B2817-5 5 mg
$275.00
More Sizes Get Quote

Product Details

Alternate Name rel-tetrahydro-4-methylene-5-oxo-2R-propyl-3S-furancarboxylic acid
Appearance Crystalline solid
CAS # 778649-18-6
Molecular Formula C₉H₁₂O₄
Molecular Weight 184.19
Purity ≥95%
Solubility ~2 mg/ml in PBS, pH 7.2
~14 mg/ml in ethanol and DMSO
SMILES CCCC1C(C(=C)C(=O)O1)C(=O)O
InChi InChI=1S/C9H12O4/c1-3-4-6-7(8(10)11)5(2)9(12)13-6/h6-7H,2-4H2,1H3,(H,10,11)/t6-,7+/m0/s1
InChi Key SRQUTZJZABSZRQ-NKWVEPMBSA-N
PubChem CID 10081070
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.

Details

Butyrolactone 3 is an inhibitor of histone acetyltransferase (HAT) Gcn5. Gcn5 acetylates histones H2B and H3. Butyrolactone 3 inhibits Gcn5 with an IC₅₀ value of 100 μM. It has an affinity to the Gcn5 enzyme similar to its substrate, histone H3. It inhibits pre-mRNA splicing with an IC₅₀ of 0.5 mM.


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