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Busulfan

A bifunctional alkylating agent
Catalog #: B1063
SKU-Size Size Price Qty
B1063-1G 1 g
$65.00
B1063-5G 5 g
$185.00
More Sizes Get Quote

Product Details

Alternate Name 1,4-Butanediol dimethanesulfonate
Appearance White solid
CAS # 55-98-1
Molecular Formula C₆H₁₄O₆S₂
Molecular Weight 246.3
Purity ≥97%
Solubility DMSO
SMILES CS(=O)(=O)OCCCCOS(=O)(=O)C
InChi InChI=1S/C6H14O6S2/c1-13(7,8)11-5-3-4-6-12-14(2,9)10/h3-6H2,1-2H3
InChi Key COVZYZSDYWQREU-UHFFFAOYSA-N
PubChem CID 2478
MDL Number MFCD00007562
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. Busulfan causes DNA damage by cross-linking DNA and proteins. Causes double-base lesions mainly at 5'-GA-3' and, to a lesser extent, at 5'-GG-3' sequences. Forms an intrastrand cross-link at the 5'-GA-3' sequence, and to monoalkylation. Induces normal human fibroblast senescence selectively through Erk and p38 pathways.


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