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Bufalin

A specific Na⁺/K⁺-ATPase inhibitor
Catalog #: 2509
SKU-Size Size Price Qty
2509-10 10 mg
$85.00
2509-50 50 mg
$335.00
More Sizes Get Quote

Product Details

Alternate Name 3β,14-Dihydroxy-5β,20(22)-bufadienolide, 5β,20(22)-Bufadienolide-3β,14-diol
Appearance White to off-white solid
CAS # 465-21-4
Molecular Formula C₂₄H₃₄O₄
Molecular Weight 386.52
Purity ≥98% by HPLC
Solubility DMSO (~25 mg/ml) or EtOH (~ 25 mg/ml, warm)
SMILES CC12CCC(CC1CCC3C2CCC4(C3(CCC4C5=COC(=O)C=C5)O)C)O
InChi InChI=1S/C24H34O4/c1-22-10-7-17(25)13-16(22)4-5-20-19(22)8-11-23(2)18(9-12-24(20,23)27)15-3-6-21(26)28-14-15/h3,6,14,16-20,25,27H,4-5,7-13H2,1-2H3/t16-,17+,18-,19+,20-,22+,23-,24+/m1/s1
InChi Key QEEBRPGZBVVINN-BMPKRDENSA-N
PubChem CID 9547215
MDL Number MFCD00056525
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Bufalin is cardioactive steroid that exhibits a variety of biological activities, such as cardiotonic, anaesthetic, blood pressure stimulatory, respiratory and antineoplastic effects. Acts as a specific Na⁺/K⁺-ATPase inhibitor. More potent than ouabain. Induces cell differentiation. Induces apoptosis in U937 and HL-60 cells by activation of AP-1 via a MAPK pathway that involves JNK. Regulates Tiam1 gene. Down regulates expression of 14-3-3 protein.


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