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BTK Inhibitor, PCI-32765

A potent Bruton's Tyrosine Kinase (BTK) inhibitor
Catalog #: 2298
SKU-Size Size Price Qty
2298-5 5 mg
$135.00
2298-25 25 mg
$495.00
More Sizes Get Quote

Product Details

Alternate Name 2-propen-1-one, 1-((3R)-3-(4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo(3,4-d)pyrimidin-1-yl)-1-piperidinyl)-; Ibrutinib; CRA-032765
Peptide Sequence No
Appearance White solid
CAS # 936563-96-1
Molecular Formula C₂₅H₂₄N₆O₂
Molecular Weight 440.5
Purity ≥98% by HPLC
Solubility DMSO (>80 mg/ml)
SMILES C=CC(=O)N1CCCC(C1)N2C3=C(C(=N2)C4=CC=C(C=C4)OC5=CC=CC=C5)C(=NC=N3)N
InChi InChI=1S/C25H24N6O2/c1-2-21(32)30-14-6-7-18(15-30)31-25-22(24(26)27-16-28-25)23(29-31)17-10-12-20(13-11-17)33-19-8-4-3-5-9-19/h2-5,8-13,16,18H,1,6-7,14-15H2,(H2,26,27,28)
InChi Key XYFPWWZEPKGCCK-UHFFFAOYSA-N
PubChem CID 16126651
MDL Number MFCD20261150
Handling Protect from air and light
Storage Conditions -20 ̊C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A potent and highly selective small-molecule inhibitor of Bruton's tyrosine kinase (BTK) (IC₅₀ = 0.5 nM) with potential antineoplastic activity. It.binds to and irreversibly inhibits BTK activity, thereby preventing both B-cell activation and B-cell-mediated signaling. This leads to an inhibition of the growth of malignant B cells that overexpress BTK.


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