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BT2 (BCKDC Kinase Inhibitor)

A BCKDC kinase inhibitor
Catalog #: B2764
SKU-Size Size Price Qty
B2764-10 10 mg
B2764-50 50 mg
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Product Details

Alternate Name 3,6-Dichlorobenzo[b]thiophene-2-carboxylic acid
Peptide Sequence N/A
Appearance Off-white solid
CAS # 34576-94-8
Molecular Formula C₉H₄Cl₂O₂S
Molecular Weight 247.1
Purity ≥98% by HPLC
Solubility ~20 mg/ml DMSO
InChi InChI=1S/C9H4Cl2O2S/c10-4-1-2-5-6(3-4)14-8(7(5)11)9(12)13/h1-3H,(H,12,13)
PubChem CID 739884
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


BT2 is an inhibitor of the mitochondrial branched-chain a-ketoacid dehydrogenase complex kinase (BCKDC) - IC50 = 3.19 µM. Inhibition of this kinase has been shown to reduce levels of branched-chain amino acid concentrations in vivo. BT2 also acts as a moderate inhibitor (Ki = 59 µM) of myeloid cell leukemia 1(Mcl 1), a Bcl-2 family protein.

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