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BS-181 dihydrochloride

A potent and selective CDK7 inhibitor
Catalog #: B2180
SKU-Size Size Price Qty
B2180-5 5 mg
B2180-25 25 mg
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Product Details

Alternate Name N5-(6-Aminohexyl)-3-(1-methylethyl)-N7-(phenylmethyl)pyrazolo[1,5-a]pyrimidine-5,7-diamine dihydrochloride
Appearance White solid
CAS # 1092443-52-1 (free base)
Molecular Formula C₂₂H₃₂N₆.2HCl
Molecular Weight 453.45
Purity ≥97% by HPLC
Solubility DMSO (>40 mg/ml) or H2O (>40 mg/ml)
InChi InChI=1S/C22H32N6.ClH/c1-17(2)19-16-26-28-21(25-15-18-10-6-5-7-11-18)14-20(27-22(19)28)24-13-9-4-3-8-12-23;/h5-7,10-11,14,16-17,25H,3-4,8-9,12-13,15,23H2,1-2H3,(H,24,27);1H
PubChem CID 49867928
Handling Protect from air and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


BS-181 dihydrochloride is a potent and selective CDK7 inhibitor (IC₅₀ = 21 nM). It displays >40-fold selectivity for CDK7 over others CDKs. Promotes cell cycle arrest and apoptosis in a range of cancer cells in vitro and inhibits MCF-7 tumor xenograft growth in mice.

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