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Bromosporine

A bromodomain family inhibitor
Catalog #: 2652
SKU-Size Size Price Qty
2652-1 1 mg
$75.00
2652-5 5 mg
$295.00
More Sizes Get Quote

Product Details

Alternate Name Ethyl (3-methyl-6-(4-methyl-3-(methylsulfonamido)phenyl)-[1,2,4]triazolo[4,3-b]pyridazin-8-yl)carbamate
Appearance White solid
CAS # 1619994-69-2
Molecular Formula C₁₇H₂₀N₆O₄S
Molecular Weight 404.44
Purity ≥98% by HPLC
Solubility DMSO (~35 mg/ml) or EtOH (~ 10 mg/ml)
SMILES O=C(OCC)NC1=CC(C2=CC=C(C)C(NS(=O)(C)=O)=C2)=NN3C1=NN=C3C
InChi InChI=1S/C17H20N6O4S/c1-5-27-17(24)18-15-9-14(21-23-11(3)19-20-16(15)23)12-7-6-10(2)13(8-12)22-28(4,25)26/h6-9,22H,5H2,1-4H3,(H,18,24)
InChi Key UYBRROMMFMPJAN-UHFFFAOYSA-N
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Bromosporine is a broad spectrum bromodomain inhibitor (IC₅₀s = 0.41 µM, 0.29 µM, 0.122 µM and 0.017 µM for BRD2, BRD4, BRD9 and CECR2, respectively). At 1 µM, Bromosporine accelerates FRAP recovery of BRD4 and CREBBP, while displaying no activities against TIF1α, BAZ2A, and SMARCA2 even at 10 µM.


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