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Bromocryptine (mesylate)

A potent and specific inhibitor of Cytochrome P450 3A and dopamine D2 receptor agonist
Catalog #: 2916

In stock

SKU-Size Size Price Qty
2916-50 50 mg
$75.00
2916-250 250 mg
$255.00
More Sizes Get Quote

Product Details

Alternate Name (5α)-2-bromo-12'-hydroxy-2'-(1-methylethyl)-5'-(2-methylpropyl)-errgotaman-3',6',18-trione, monomethanesulfonate, 2-Bromo-alpha-ergocryptine, CB-154, Parlodel, Cycloset
Appearance Crystalline solid
CAS # 22260-51-1
Molecular Formula C₃₂H₄₀BrN₅O₅• CH₃SO₃H
Molecular Weight 750.7
Purity ≥98%
Solubility DMSO or DMF (~30 mg/ml), Ethanol (~5 mg/ml)
SMILES CC(C)CC1C(=O)N2CCCC2C3(N1C(=O)C(O3)(C(C)C)NC(=O)C4CN(C5CC6=C(NC7=CC=CC(=C67)C5=C4)Br)C)O.CS(=O)(=O)O
InChi InChI=1S/C32H40BrN5O5.CH4O3S/c1-16(2)12-24-29(40)37-11-7-10-25(37)32(42)38(24)30(41)31(43-32,17(3)4)35-28(39)18-13-20-19-8-6-9-22-26(19)21(27(33)34-22)14-23(20)36(5)15-18;1-5(2,3)4/h6,8-9,13,16-18,23-25,34,42H,7,10-12,14-15H2,1-5H3,(H,35,39);1H3,(H,2,3,4)/t18-,23-,24+,25+,31-,32+;/m1./s1
InChi Key NOJMTMIRQRDZMT-NEKRQHSLSA-N
PubChem CID 16219016
MDL Number MFCD00069218
Handling Protect from air, light and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Bromocriptine is a potent Cytochrome P450 3A inhibitor (~770 nM, see cat#K702). It also acts as a dopamine receptor agonist via the D2 receptor (Ki = 2.5 nM). As a result, it is used in combination therapy for Parkinsons disease. It also binds to the serotonin receptors 5-HT1A and 5-HT1D (Ki = 12.9 and 10.7 nM, respectively), as well as α and β adrenoreceptors and inhibits neuronal nitric oxide synthase (IC50 = 10 µM).


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