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Brefeldin A

Disruptor of Golgi apparatus
Catalog #: 1560
SKU-Size Size Price Qty
1560-5 5 mg
1560-50 50 mg
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Product Details

Alternate Name Ascotoxin, BFA, Cyanein, Decumbin, γ,4-Dihydroxy-2-(6-hydroxy-1-heptenyl)-4-cyclopentanecrotonic acid λ-lactone
Appearance White solid
CAS # 20350-15-6
Molecular Formula C₁₆H₂₄O₄
Molecular Weight 280.36
Purity ≥99%
Solubility DMSO or EtOH (10 mg/ml)
InChi InChI=1S/C16H24O4/c1-11-5-3-2-4-6-12-9-13(17)10-14(12)15(18)7-8-16(19)20-11/h4,6-8,11-15,17-18H,2-3,5,9-10H2,1H3
PubChem CID 2430
MDL Number MFCD12913297
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.


Brefeldin A has been shown to induce apoptosis in human tumor cells through caspase activation. It has also been shown to block translocation of proteins from the endoplasmic reticulum to the Golgi apparatus.

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Andrew S. Nelson, Oral therapy with colonization factor antigen I prevents development of type 1 diabetes in Non-obese Diabetic mice. Sci Rep., Apr. 2020;  32273533.
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