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A specific inhibitor of euchromatin histone methyltransferase G9a (EHMT2)
Catalog #: B2810
SKU-Size Size Price Qty
B2810-1 1 mg
B2810-5 5 mg
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Product Details

Alternate Name BRD9539
2-benzamido-1-(3-phenylpropyl)benzimidazole-5-carboxylic acid
Appearance Crystalline solid
CAS # 1374601-41-8
Molecular Formula C₂₄H₂₁N₃O₃
Molecular Weight 399.44
Purity ≥98%
Solubility 0.5 mg/ml in Ethanol
10 mg/ml in DMSO and DMF
InChi InChI=1S/C24H21N3O3/c28-22(18-11-5-2-6-12-18)26-24-25-20-16-19(23(29)30)13-14-21(20)27(24) 15-7-10-17-8-3-1-4-9-17/h1-6,8-9,11-14,16H,7,10,15H2,(H,29,30)(H,25,26,28)
PubChem CID 73755260
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


BRD9539 is a specific inhibitor of euchromatin histone methyltransferase G9a (EHMT2). EHMT2 catalyzes the methylation of lysine 9 on histone H3. BRD9539 inhibits EHMT2 with an IC₅₀ of 6.3 μM. It also inhibits methyl transferase PRC2 with a similar IC₅₀. It is the methyl-ester analogue of BRD4770. It is more potent than BRD4770 in enzyme assays but does not show activity in cell-based assays, probably due to impaired cell permeability compared to that of BRD4770.

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