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BRD9539

A specific inhibitor of euchromatin histone methyltransferase G9a (EHMT2)
Catalog #: B2810
SKU-Size Size Price Qty
B2810-1 1 mg
$55.00
B2810-5 5 mg
$195.00
More Sizes Get Quote

Product Details

Alternate Name BRD9539
2-benzamido-1-(3-phenylpropyl)benzimidazole-5-carboxylic acid
Appearance Crystalline solid
CAS # 1374601-41-8
Molecular Formula C₂₄H₂₁N₃O₃
Molecular Weight 399.44
Purity ≥98%
Solubility 0.5 mg/ml in Ethanol
10 mg/ml in DMSO and DMF
SMILES C1=CC=C(C=C1)CCCN2C3=C(C=C(C=C3)C(=O)O)N=C2NC(=O)C4=CC=CC=C4
InChi InChI=1S/C24H21N3O3/c28-22(18-11-5-2-6-12-18)26-24-25-20-16-19(23(29)30)13-14-21(20)27(24) 15-7-10-17-8-3-1-4-9-17/h1-6,8-9,11-14,16H,7,10,15H2,(H,29,30)(H,25,26,28)
InChi Key WPXMEOBILYVKBC-UHFFFAOYSA-N
PubChem CID 73755260
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

BRD9539 is a specific inhibitor of euchromatin histone methyltransferase G9a (EHMT2). EHMT2 catalyzes the methylation of lysine 9 on histone H3. BRD9539 inhibits EHMT2 with an IC₅₀ of 6.3 μM. It also inhibits methyl transferase PRC2 with a similar IC₅₀. It is the methyl-ester analogue of BRD4770. It is more potent than BRD4770 in enzyme assays but does not show activity in cell-based assays, probably due to impaired cell permeability compared to that of BRD4770.


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