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BRD3-Bromodomain1 (29-145 aa) (His-Tagged) human recombinant

A protein involved in chromatin targeting
Catalog #: 7256
SKU-Size Size Price Qty
7256-20 20 μg
$195.00
7256-100 100 μg
$595.00
7256-1000 1 mg
$4,850.00
More Sizes Get Quote

Product Details

Alternate Name KIAA0043, RING3L
Gene Symbol BRD3
Gene ID 8019
Accession # Q15059
Source E. coli
Appearance Liquid
Physical Form Description rh-BRD3-BD1 is supplied as a solution in PBS Buffer containing 10% glycerol
Molecular Weight 16.2 kDa
Purity by SDS-PAGE ≥98%
Handling Centrifuge the vial prior to opening.
Storage Conditions -80°C
Shipping Conditions Dry Ice
USAGE For Research Use Only! Not to be used in humans

Details

The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as “readers” of histone acetylation marks regulating the transcription of target promoters. BRD3 binds hyper-acetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors. It regulates transcription by promoting the binding of the transcription factor GATA1 to its targets and transcription of the CCND1 gene. A chromosomal aberration involving BRD3 was found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. The recombinant protein includes Bromodomain-containing protein 3 (contains 29-145 aa) with N-terminal His-tag.


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