A delective CARD9 inhibitor
Catalog #: B3293 | abID:

Product Details

Alternate Name 2-(4'-Carbamoyl-[1,4'-bipiperidin]-1'-yl)-5-(4-methylbenzamido)nicotinic acid
Peptide Sequence N/A
Appearance Crystalline solid
CAS # 1358488-78-4
Molecular Formula C₂₅H₃₁N₅O₄
Molecular Weight 465.54
Purity ≥98% by HPLC
Solubility ~2 mg/ml DMSO
InChi InChI=1S/C25H31N5O4/c1-17-5-7-18(8-6-17)22(31)28-19-15-20(23(32)33)21(27-16-19)29-13-9-25(10-14-29,24(26)34)30-11-3-2-4-12-30/h5-8,15-16H,2-4,9-14H2,1H3,(H2,26,34)(H,28,31)(H,32,33)
PubChem CID 83288403
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


BRD-5529 is a selective, cell-permeable CARD9-E3 ubiquitin ligase TRIM62 protein-protein interaction inhibitor (IC50 of 8.6 μM). BRD-5529 directly and selectively binds CARD9, disrupts TRIM62 recruitment, inhibits TRIM62-mediated ubiquitinylation and activation of CARD9, and demonstrates cellular activity and selectivity in CARD9-dependent pathways.

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