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BQ-123 Sodium Salt

A potent and selective ETA endothelin receptor antagonist
Catalog #: B1552

In stock

SKU-Size Size Price Qty
B1552-1 1 mg
B1552-5 5 mg
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Product Details

Alternate Name Cyclo (D-Trp-D-Asp-Pro-D-Val-Leu) ; Endothelin Receptor A Antagonist BQ-123
Peptide Sequence Cyclo (D-Trp-D-Asp-Pro-D-Val-Leu)
Appearance White lyophilized solid
CAS # 136553-81-6 (Free acid)
Molecular Formula C₃₁H₄₁N₆O₇•Na
Molecular Weight 632.69
Purity ≥95% by HPLC
Solubility H₂O
InChi InChI=1S/C31H42N6O7/c1-16(2)12-21-27(40)33-22(13-18-15-32-20-9-6-5-8-19(18)20)28(41)35-23(14-25(38)39)31(44)37-11-7-10-24(37)29(42)36-26(17(3)4)30(43)34-21/h5-6,8-9,15-17,21-24,26,32H,7,10-14H2,1-4H3,(H,33,40)(H,34,43)(H,35,41)(H,36,42)(H,38,39)/t21-,22+,23+,24-,26+/m0/s1
PubChem CID 443289
MDL Number MFCD00133204
Handling Protect from air and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


BQ-123 sodium is a potent and selective ETA endothelin receptor antagonist (Ki values are 1.4 and 1500 nM at ETA and ETB receptors respectively). It also inhibits ET-1 receptor binding and blocks Ca²⁺ mobilization, cellular contraction and MAP kinase activation.

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