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BPTF bromodomain (2796-2907 aa) (GST-tagged), Human recombinant

An essential regulator of gene expression
Catalog #: 7662
$595.00

Product Details

Cat # +Size 7662-100
Size 100 μg
Alternate Name Bromodomain PHD Finger Transcription Factor
Gene Symbol BPTF
Gene ID 2186
Accession # Q12830
Source E. coli
Appearance Liquid
Physical Form Description 50 mM Tris, pH 7.5, containing 500 mM sodium chloride, 5 mM β-mercaptoethanol and 5% glycerol.
Molecular Weight 40.1 kDa (2796-2907 aa + NT GST Tag)
Purity by SDS-PAGE ≥80%
Handling Centrifuge the vial prior to opening.
Storage Conditions -80°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as “readers” of histone acetylation marks regulating the transcription of target promoters. BPTF is the largest component of the NURF chromatin remodeling complex. It includes adjacent PHD and bromodomains which recognize trimethylation of H3K4 or acetylation of lysines in histone 4, respectively. BPTF is an essential regulator of gene expression in early mouse embryos, and its knock-out is embryonic lethal. Duplication of the BPTF gene has been suggested to increase proliferation of cultured cancer cells, and aberrant BPTF copy numbers were found in 42% of the “NCI-60” panel of 60 human cancer cell lines. This protein product contains the bromodomain of BPTF.


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