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Bosutinib (SKI-606)

based on 2 citations in multiple journalsBosutinib (SKI-606)24.1 4
A protein tyrosine kinase (PTK) inhibitor
Catalog #: 1584

In stock

SKU-Size Size Price Qty
1584-5 5 mg
$100.00
1584-25 25 mg
$205.00
More Sizes Get Quote

Product Details

Alternate Name SKI-606
Appearance White to off-white solid
CAS # 380843-75-4
Molecular Formula C₂₆H₂₉Cl₂N₅O₃
Molecular Weight 530.45
Purity ≥99% by HPLC
Solubility DMSO (30 mg/ml) or EtOH (10 mg/ml)
SMILES CN1CCN(CC1)CCCOC2=CC3=NC(=CC(=C3C=C2OC)NC4=CC(=C(C=C4Cl)Cl)OC)C#N
InChi InChI=1S/C26H29Cl2N5O3/c1-32-6-8-33(9-7-32)5-4-10-36-26-14-22-18(12-25(26)35-3)21(11-17(16-29)30-22)31-23-15-24(34-2)20(28)13-19(23)27/h11-15H,4-10H2,1-3H3,(H,30,31)
InChi Key ALUXPRDJABOEAG-UHFFFAOYSA-N
PubChem CID 46926609
MDL Number MFCD07367846
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.

Details

Bosutinib (SKI-606) is a novel tyrosine kinase inhibitor. Bosutinib can overcome not only Bcr-Abl-dependent mechanisms of resistance, but also those that are Bcr-Abl-independent. It is used to treat patients with chronic myelogenous leukemia (CML) who demonstrate resistance to Imatinib or develop resistance during treatment.


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Ho et al., Tubedown regulation of retinal endothelial permeability signaling pathways. Biology Open, Aug 2015; 4: 970 - 979.
Lee et al., Gas6/Axl pathway promotes tumor invasion through the transcriptional activation of Slug in hepatocellular carcinoma. Carcinogenesis, Apr 2014; 35: 769 - 775.
For more citations of this product click here