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An angiogenesis inhibitor
Catalog #: 2367
SKU-Size Size Price Qty
2367-250 250 µg
2367-1000 1 mg
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Product Details

Alternate Name Treponemycin; U 78548; C2989
Appearance White to off-white solid
CAS # 7184-60-3
Molecular Formula C₂₈H₄₃NO₆
Molecular Weight 489.64
Purity ≥98% by HPLC
Solubility DMSO (~10 mg/ml)
InChi InChI=1S/C28H43NO6/c1-17-12-18(2)14-20(4)27(32)21(16-29)8-5-6-11-25(22-9-7-10-23(22)28(33)34)35-26(31)15-24(30)19(3)13-17/h5-6,8,17-20,22-25,27,30,32H,7,9-15H2,1-4H3,(H,33,34)/b6-5+,21-8-/t17-,18+,19-,20-,22+,23+,24-,25-,27+/m0/s1
PubChem CID 6436801
MDL Number MFCD01740784
Handling Protect from light and moisture
Storage Conditions -20 ̊C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


A macrolide antibiotic isolated from Streptomyces sp. An antiangiogenic (IC₅₀ = 0.8 nM) agent. Bacterial and eukaryal threonyl-tRNA synthetase (THrRS) inhibitor. Induces the collapse of formed capillary tubes in a dose-dependent fashion. In HUVECs, the capillary tube collapsing activity is mediated by the activation of caspases-3 and -8 and induction of apoptosis. Also acts as a CDK inhibitor.

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