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Boromycin

A boron-containing macrolide antibiotic
Catalog #: B3224
SKU-Size Size Price Qty
B3224-250 250 μg
$135.00
B3224-1000 1 mg
$425.00
More Sizes Get Quote

Product Details

Alternate Name NSC-121380;
(T-4)-[(1R)-1-[(1S,2R,5S,6R,8R,12R,14S,17R,18S,19R,22S,24Z,28S,30S,33R)-
1,2,18,19-tetra(hydroxy-κO)-12,28-dihydroxy-6,13,13,17,29,29,33-heptamethyl-
3,20-dioxo-4,7,21,34,35-pentaoxatetracyclo[28.3.1.15,8.114,18]hexatriacont-24-en-22-yl]ethyl D-valinato(4-)]-borate(1-), monohydrogen
Peptide Sequence N/A
Appearance Off-white solid
CAS # 34524-20-4
Molecular Formula C₄₅H₇₄BNO₁₅
Molecular Weight 879.9
Purity ≥98%
Solubility DMSO
SMILES [H][[email protected]@]12O[B-]34O[[email protected]@H](C(=O)O[[email protected]@]([H])(C\C=C/CC[[email protected]](O)C(C)(C)[[email protected]]5([H])CC[[email protected]@H](C)[[email protected]@]1(O3)O5)[[email protected]@H](C)OC(=O)[[email protected]]([NH3+])C(C)C)[[email protected]]1(O4)O[[email protected]@]([H])(CC[[email protected]]1C)C(C)(C)[[email protected]](O)CCC[[email protected]@H]1C[[email protected]](OC2=O)[[email protected]@H](C)O1
InChi InChI=1S/C45H73BNO15/c1-24(2)36(47)39(50)54-27(5)30-16-12-11-13-17-32(48)42(7,8)34-21-19-26(4)45(57-34)38-41(52)56-31-23-29(53-28(31)6)15-14-18-33(49)43(9,10)35-22-20-25(3)44(58-35)37(40(51)55-30)59-46(60-38,61-44)62-45/h11-12,24-38,48-49H,13-23,47H2,1-10H3/q-1/p+1/b12-11+/t25-,26-,27-,28-,29-,30+,31+,32+,33-,34+,35+,36-,37?,38?,44+,45+,46?/m1/s1
InChi Key OOBFYEMEQCZLJL-XURNZCJASA-O
PubChem CID 6436027
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Boromycin is a boron-containing macrolide antibiotic that displays antibacterial, and antiprotozoal properties. Boromycin (3.4 nM) reverses bleomycin-induced cell cycle arrest at the G2 phase in Jurkat cells. It inhibits replication of the HIV-1 strains LAV-1 and RF and the HIV-2 strain LAV-2 in MT-4 cells (IC50s = 0.008, 0.11, and 0.007 µM, respectively. It also inhibits replication of a clinical isolate of HIV-1, strain KK-1, in MT-4 cells and peripheral blood mononuclear cells.


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