BODIPY-Cyclopamine

A Shh signaling inhibitor
Catalog #: 2160 | abID: ab285383

Product Details

abID ab285383
Appearance Red solid
CAS # 334658-24-1
Molecular Formula C₄₉H₇₀BF₂N₅O₄
Molecular Weight 841.92
Purity ≥95% by TLC
Solubility DMSO
SMILES [B-]1(N2C(=CC(=C2C=C3[N+]1=C(C=C3)CCC(=O)NCCCCCC(=O)NCCN4CC(CC5C4C(C6(O5)CCC7C8CC=C9CC(CCC9(C8CC7=C6C)C)O)C)C)C)C)(F)F
InChi InChI=1S/C49H70BF2N5O4/c1-30-24-44-47(34(5)49(61-44)20-18-39-40-15-11-35-26-38(58)17-19-48(35,6)42(40)28-41(39)33(49)4)55(29-30)23-22-54-45(59)10-8-7-9-21-53-46(60)16-14-36-12-13-37-27-43-31(2)25-32(3)56(43)50(51,52)57(36)37/h11-13,25,27,30,34,38-40,42,44,47,58H,7-10,14-24,26,28-29H2,1-6H3,(H,53,60)(H,54,59)/t30?,34?,38-,39?,40?,42?,44+,47?,48?,49?/m0/s1
InChi Key CQPRECBXTRAUSE-QEXJUGOOSA-N
PubChem CID 71314179
Handling Protect from light and mositure
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A fluorescent Cyclopamine (Cat. No. 1578-5) derivative that retains potency in Shh signaling inhibition (IC₅₀ = 150 nM).


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Khaliullina et al., Endocannabinoids are conserved inhibitors of the Hedgehog pathway. PNAS, Mar 2015; 112: 3415 - 3420.
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