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Boc-D-FMK

based on 3 citations in multiple journalsBoc-D-FMK34.1 4
A caspase family inhibitor
Catalog #: 1160
SKU-Size Size Price Qty
1160-1 1 mg
$155.00
1160-5 5 mg
$445.00
More Sizes Get Quote

Product Details

Alternate Name Boc-D-FMK, Boc-D-fluoromethylketone, Caspase Inhibitor (fluoromethylketone)
Peptide Sequence Boc-Asp(OMe)-FMK
Appearance Lyophilized solid
Molecular Formula C₁₁H₁₈FNO₅
Molecular Weight 263.26
Purity >95% by HPLC
Solubility DMSO (20 mM)
SMILES CC(C)(C)OC(=O)NC(CC(=O)OC)C(=O)CF
InChi InChI=1S/C11H18FNO5/c1-11(2,3)18-10(16)13-7(8(14)6-12)5-9(15)17-4/h7H,5-6H2,1-4H3,(H,13,16)
InChi Key MXOOUCRHWJYCAL-UHFFFAOYSA-N
PubChem CID 16760348
MDL Number MFCD03453073
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A synthetic peptide that irreversibly inhibits activity of caspase family proteases and blocks apoptosis. The inhibitor is designed as a methyl ester to facilitate cell permeability. The product can be used for both in vitro and in vivo studies. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).


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Natoni, A. et. al. Mechanisms of Action of a Dual Cdc7/Cdk9 Kinase Inhibitor against Quiescent and Proliferating CLL Cells. Mol. Cancer Ther., Sep 2011; 10: 1624 - 1634.
Oshikawa, G. et. al. c-Cbl and Cbl-b Ligases Mediate 17-Allylaminodemethoxygeldanamycin-induced Degradation of Autophosphorylated Flt3 Kinase with Internal Tandem Duplication through the Ubiquitin Proteasome Pathway. J. Biol. Chem., Sep 2011; 286: 30263 - 30273.
Kurosu T et al (2009) Cancer Res.; 69: 3927 - 3936.
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