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Product Details
| Alternate Name | Bobcat-339; 1-([1,1'-biphenyl]-3-yl)-4-amino-5-chloropyrimidin-2(1H)-one |
|---|---|
| Peptide Sequence | N/A |
| Appearance | White to off-white solid |
| CAS # | 2280037-51-4 |
| Molecular Formula | C₁₆H₁₂ClN₃O |
| Molecular Weight | 297.74 |
| Purity | ≥98% |
| Solubility | ~1 mg/ml DMSO |
| SMILES | C1=CC=C(C=C1)C2=CC(=CC=C2)N3C=C(C(=NC3=O)N)Cl |
| InChi | InChI=1S/C16H12ClN3O/c17-14-10-20(16(21)19-15(14)18)13-8-4-7-12(9-13)11-5-2-1-3-6-11/h1-10H,(H2,18,19,21) |
| InChi Key | QMGYGOOYCNTEQO-UHFFFAOYSA-N |
| PubChem CID | 138319673 |
| Handling | Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure. |
| Storage Conditions | -20ºC |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Bobcat339 is a potent cytosine-based TET (ten-eleven translocation methylcytosine dioxygenase) enzyme inhibitor with IC50 of 33 µM (TET1) and 73 µM (TET2). Bobcat339 does not inhibit the DNA methyltransferase, DNMT3a. Bobcat339 can reduce DNA 5-hydroxymethylcytosine abundance by inhibiting TET enzyme function in living cells and provide support for its utility as a viable pharmacological probe.
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