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Bobcat339 (free base)

A TET enzyme inhibitor
Catalog #: B3249
SKU-Size Size Price Qty
B3249-5 5 mg
B3249-25 25 mg
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Product Details

Alternate Name Bobcat-339; 1-([1,1'-biphenyl]-3-yl)-4-amino-5-chloropyrimidin-2(1H)-one
Peptide Sequence N/A
Appearance White to off-white solid
CAS # 2280037-51-4
Molecular Formula C₁₆H₁₂ClN₃O
Molecular Weight 297.74
Purity ≥98%
Solubility ~1 mg/ml DMSO
InChi InChI=1S/C16H12ClN3O/c17-14-10-20(16(21)19-15(14)18)13-8-4-7-12(9-13)11-5-2-1-3-6-11/h1-10H,(H2,18,19,21)
PubChem CID 138319673
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Bobcat339 is a potent cytosine-based TET (ten-eleven translocation methylcytosine dioxygenase) enzyme inhibitor with IC50 of 33 µM (TET1) and 73 µM (TET2). Bobcat339 does not inhibit the DNA methyltransferase, DNMT3a. Bobcat339 can reduce DNA 5-hydroxymethylcytosine abundance by inhibiting TET enzyme function in living cells and provide support for its utility as a viable pharmacological probe.

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