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Bnip3L/Nix Antibody

Catalog #: 3205
$245.00

Product Details

Cat # +Size 3205-100
Size 100 µg
Antibody Target Bnip3L/Nix
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Synthetic peptide surrounding amino acid 80 of human Bnip3L.
Accession # O60238
Gene ID 665
Appearance Colorless liquid
Concentration 0.5 mg/ml
Formulation 100 µg (0.5 mg/ml) affinity purified rabbit anti-Bnip3L polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 1% BSA, 0.02% thimerosal.
Purification Affinity purified
Species Reactivity Human, mouse
Application Western blot, Immunohistochemistry
Application & Usage The antibody can be used for Western blot analysis (0.5-2 µg/ml) and immunohistochemistry (2-10 µg/ml). The optimal conditions should be determined individually. Other applications have not been tested.
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Members of Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, Hrk, Nip3, and Bim, form a growing subclass of the Bcl-2 family. A novel BH3 domain containing protein was recently identified and designated Bnip3L, Bnip3α, and Nix (for Nip3-like protein X). Bnip3L/Bnip3α/Nix is a homolog of the E1B 19K/Bcl-2 binding and pro-apoptotic protein Bnip3. Overexpression of Bnip3L induces apoptosis. Bnip3L interacts with and overcomes supression by Bcl-2 and Bcl-xL. Bnip3L is localized in mitochondria. The message RNA of Bnip3L and Bnip3 form a new subfamily of the proapoptotic mitochondrial proteins.


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