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BMS-986142

A potent, selective, and reversible BTK inhibitor
Catalog #: B2420
SKU-Size Size Price Qty
B2420-1 1 mg
$135.00
B2420-5 5 mg
$535.00
More Sizes Get Quote

Product Details

Alternate Name BMS986142, (2S,5R,3S)-6-fluoro-5-(3-(8-fluoro-1-methyl-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl) -2-methylphenyl)-2-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1H-carbazole-8-carboxamide
Appearance White to off-white solid
CAS # 1643368-58-4
Molecular Formula C₃₂H₃₀F₂N₄O₄
Molecular Weight 572.61
Purity ≥98% by HPLC
Solubility >40 mg/ml in DMSO
SMILES CC1=C(C=CC=C1N2C(=O)C3=C(C(=CC=C3)F)N(C2=O)C)C4=C(C=C(C5=C4C6=C(N5)CC(CC6)C(C)(C)O)C(=O)N)F
InChi InChI=1S/C32H30F2N4O4/c1-15-17(7-6-10-24(15)38-30(40)19-8-5-9-21(33)28(19)37(4)31(38)41)25-22(34) 14-20(29(35)39)27-26(25)18-12-11-16(32(2,3)42)13-23(18)36-27/h5-10,14,16,36,42H,11-13H2,1-4H3, (H2,35,39)/t16-/m0/s1
InChi Key ZRYMMWAJAFUANM-INIZCTEOSA-N
PubChem CID 86582336
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

BMS-986142 is a potent, selective, and reversible BTK (Bruton’s tyrosine kinase) inhibitor (BTK IC₅₀ = 0.5nM; human WB IC₅₀ = 90 nM). BMS-986142 displays robust efficacy in murine models of rheumatoid arthritis (RA), including collagen-induced arthritis (CIA) and collagen antibody-induced arthritis (CAIA).


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