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BMS-986158

A potent bromodomain (BRD) and extra-terminal domain (BET) family inhibitor
Catalog #: B2021
SKU-Size Size Price Qty
B2021-1 1 mg
$85.00
B2021-5 5 mg
$335.00
More Sizes Get Quote

Product Details

Alternate Name (S)-2-(3-(1,4-dimethyl-1H-1,2,3-triazol-5-yl)-5-(phenyl(tetrahydro-2H-pyran-4-yl)methyl)-5H-pyrido[3,2-b]indol-7-yl)propan-2-ol
Appearance Crystalline solid
CAS # 1800340-40-2 
Molecular Formula C₃₀H₃₃N₅O₂ 
Molecular Weight 495.63
Purity ≥98% by HPLC
Solubility DMSO
SMILES CC1=C(N(N=N1)C)C2=CC3=C(C4=C(N3C(C5CCOCC5)C6=CC=CC=C6)C=C(C=C4)C(C)(C)O)N=C2
InChi InChI=1S/C30H33N5O2/c1-19-28(34(4)33-32-19)22-16-26-27(31-18-22)24-11-10-23(30(2,3)36)17-25(24)35(26)29(20-8-6-5-7-9-20)21-12-14-37-15-13-21/h5-11,16-18,21,29,36H,12-15H2,1-4H3/t29-/m1/s1
InChi Key KGERZPVQIRYWRK-GDLZYMKVSA-N
PubChem CID 118196485
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

BMS-986158 is a potent bromodomain (BRD) and extra-terminal domain (BET) family inhibitor.  BMS-986158 binds to the acetyl-lysine binding site in the BRD of BET proteins, thereby preventing the interaction between BET proteins and acetylated histones. This disrupts chromatin remodeling and prevents the expression of certain growth-promoting genes, resulting in an inhibition of tumor cell growth.


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