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BMS-863233 hydrochloride

A potent and selective CDC7 inhibitor
Catalog #: 2598
SKU-Size Size Price Qty
2598-5 5 mg
$125.00
2598-25 25 mg
$485.00
More Sizes Get Quote

Product Details

Alternate Name (S)-8-chloro-2-(pyrrolidin-2-yl)benzofuro[3,2-d]pyrimidin-4(3H)-one hydrochloride; XL-413 hydrochloride
Appearance White to off-white solid
CAS # 1169562-71-3
Molecular Formula C₁₄H₁₃Cl₂N₃O₂
Molecular Weight 326.17
Purity >98% by HPLC
Solubility H₂O (~ 6.5 mg/ml)
SMILES C1CC(NC1)C2=NC(=O)C3=C(N2)C4=C(O3)C=CC(=C4)Cl
InChi InChI=1S/C14H12ClN3O2/c15-7-3-4-10-8(6-7)11-12(20-10)14(19)18-13(17-11)9-2-1-5-16-9/h3-4,6,9,16H,1-2,5H2,(H,17,18,19)/t9-/m0/s1
InChi Key JJWLXRKVUJDJKG-VIFPVBQESA-N
PubChem CID 57899889
Handling Protect from air and moisture
Storage Conditions -20 ̊C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

BMS-863233 is a potent and selective CDC7 (cell division cycle 7 homolog) inhibitor. BMS-863233 binds to and inhibits the activity of CDC7, resulting in the inhibition of DNA replication and mitosis, the induction of tumor cell apoptosis, and the inhibition of tumor cell proliferation in CDC7-overexpressing tumor cells. CDC7, a serine-threonine kinase overexpressed in a variety of tumor cell types, plays an essential role in the initiation of DNA replication by activating origins of replication.


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