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BMS-303141

A potent inhibitor of ATP citrate lyase (ACL)
Catalog #: 2821
SKU-Size Size Price Qty
2821-10 10 mg
$145.00
2821-50 50 mg
$585.00
More Sizes Get Quote

Product Details

Alternate Name 3,5-Dichloro-2-hydroxy-N-(4-methoxy[1,1'-biphenyl]-3-yl)-benzenesulfonamide
Appearance White solid
CAS # 943962-47-8
Molecular Formula C₁₉H₁₅Cl₂NO₄S
Molecular Weight 424.3
Purity ≥98% by HPLC
Solubility DMSO (~10 mg/ml) or EtOH (~ 20 mg/ml)
SMILES COC1=C(C=C(C=C1)C2=CC=CC=C2)NS(=O)(=O)C3=CC(=CC(=C3O)Cl)Cl
InChi InChI=1S/C19H15Cl2NO4S/c1-26-17-8-7-13(12-5-3-2-4-6-12)9-16(17)22-27(24,25)18-11-14(20)10-15(21)19(18)23/h2-11,22-23H,1H3
InChi Key SIIPNDKXZOTLEA-UHFFFAOYSA-N
PubChem CID 16747776
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

BMS-303141 is a potent inhibitor of ATP citrate lyase (ACL) (IC₅₀ = 0.13 µM for human recombinant ACL). BMS-303141 inhibits lipid synthesis in HepG2 cells with an IC₅₀ of 8 μM, and lowers plasma triglycerides in a murine hyperlipdemia model


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