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BMS-3

A potent and specific inhibitor of activated LIM domain kinases (LIMK1 and LIMK2)
Catalog #: B2298
SKU-Size Size Price Qty
B2298-5 5 mg
$95.00
B2298-25 25 mg
$375.00
More Sizes Get Quote

Product Details

Alternate Name N-[5-[1-(2,6-dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]-2-thiazolyl]-cyclopropanecarboxamide
Appearance White to off-white solid
CAS # 1338247-30-5
Molecular Formula C₁₇H₁₂Cl₂F₂N₄OS
Molecular Weight 429.27
Purity ≥97% by HPLC
Solubility DMSO (~10 mg/ml)
SMILES C1CC1C(=O)NC2=NC=C(S2)C3=CC(=NN3C4=C(C=CC=C4Cl)Cl)C(F)F
InChi InChI=1S/C17H12Cl2F2N4OS/c18-9-2-1-3-10(19)14(9)25-12(6-11(24-25)15(20)21)13-7-22-17(27-13)23-16(26)8-4-5-8/h1-3,6-8,15H,4-5H2,(H,22,23,26)
InChi Key YBGGBHCJSAEIAS-UHFFFAOYSA-N
PubChem CID 73265272
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

BMS-3 is a potent and specific inhibitor of activated LIM domain kinases LIMK1 and LIMK2 (IC₅₀s = 5 and 6 nM, respectively). LIMK1 is responsible for the inactivation of cofilin (ADF family protein), leading to actin reorganization. It is upregulated in several invasive cancers.


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