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BMS-1001 free base

A potent PD-1/PD-L1 interaction inhibitor
Catalog #: B2758
SKU-Size Size Price Qty
B2758-1 1 mg
$75.00
B2758-5 5 mg
$275.00
More Sizes Get Quote

Product Details

Alternate Name (2-((3-Cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-5-methylbenzyl)-D-serine; BMS1001
Peptide Sequence N/A
Appearance Crystalline solid
CAS # 2113650-03-4
Molecular Formula C₃₅H₃₄N₂O₇
Molecular Weight 594.66
Purity ≥98%
Solubility DMSO
SMILES OC[[email protected]](C(O)=O)NCC1=CC(C)=C(OCC2=CC=CC(C3=CC=C4OCCOC4=C3)=C2C)C=C1OCC5=CC=CC(C#N)=C5
InChi InChI=1S/C35H34N2O7/c1-22-13-28(18-37-30(19-38)35(39)40)33(43-20-25-6-3-5-24(14-25)17-36)16-32(22)44-21-27-7-4-8-29(23(27)2)26-9-10-31-34(15-26)42-12-11-41-31/h3-10,13-16,30,37-38H,11-12,18-21H2,1-2H3,(H,39,40)/t30-/m1/s1
InChi Key UWNXGZKSIKQKAH-SSEXGKCCSA-N
PubChem CID 131839624
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

BMS-1001 is a potent inhibitor of the interaction between programmed death protein 1 (PD-1) and its ligand programmed cell death ligand 1 (PD-L1) (IC50 = 2.25 nM). BMS-1001 is capable of alleviating the PD-1/PD-L1 immune checkpoint-mediated exhaustion of Jurkat T-lymphocytes


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