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BMPR2 Antibody (NT)

Polyclonal Antibody to detect BMPR2 in human and mouse samples.
Catalog #: 6780
$265.00

Product Details

Cat # +Size 6780-100
Size 100 μl
Antibody Target BMPR2
Alternate Name BMPR2; PPH1; Bone morphogenetic protein receptor type-2; Bone morphogenetic protein receptor type II
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen This BMPR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 28-59 amino acids from the N-terminal region of human BMPR2.
Accession # Q13873
Gene ID 659
Appearance Colorless liquid
Formulation In PBS with 0.09% (W/V) sodium azide.
Purification Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Species Reactivity Human, Mouse.
Application Western blot, IHC, FACS.
Positive Control Western blot: mouse heart tissue lysate, IHC: human hepatocarcinoma and kidney tissues, FACS: HepG2 cells.
Application & Usage WB: 1:1000, IHC: 1:10 – 1:50, FC: 1:10 – 1:50.
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

BMPR2 is a type II serine/threonine receptor kinase that binds to an array of secreted bone morphogenetic proteins (BMPs). BMPs belong to the superfamily of TGF-β ligands that modulate gastrulation, neurogenesis, chondrogenesis, interdigital cell death, and bone morphogenesis. In contrast to the TGF-β type II receptor, BMPR2 contains an extended carboxyl-terminal region that interacts with multiple signaling molecules to modulate the responsiveness of target genes to BMPs. BMP signaling requires oligomerization of both type I and type II receptors to elicit a functional response of target genes. BMP binding to type I and II receptors induces Smad1/5/8 phosphorylation which is required for the activation of target genes. In vitro and in vivo evidence suggests that defects in BMPR2 may contribute to pulmonary hypertension, inflammation, and endothelial injury.


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