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BMPR1A, human recombinant

A transmembrane serine/threonine kinases
Catalog #: 4881
SKU-Size Size Price Qty
4881-10 10 μg
$330.00
4881-1000 1 mg
$5,940.00
More Sizes Get Quote

Product Details

Alternate Name BMPR-1A, BMP-R1A, BMPR1A, BMR1A, CD292, CD-292, Activin receptor-like kinase 3, Serine/threonine-protein kinase receptor R5, CD_antigen=CD292
Gene Symbol BMPR1A
Gene ID 657
Accession # P36894
Source Insect cells (Baculovirus)
Appearance Lyophilized protein
Physical Form Description Lyophilized from sterile PBS.
Molecular Weight 23.0 kDa
Purity by SDS-PAGE ≥90%
Purity by ≥90%
Biological Activity Measured by its ability to inhibit recombinant human BMP-2 induced alkaline phosphatase production by C2C12 myogenic cells. The ED₅₀ for this effect is typically 1-3 µg/ml in the presence of 500 ng/ml of recombinant human BMP-2.
Reconstitution Instructions Centrifuge the vial prior to opening. Reconstitute in sterile PBS to a concentration ≥ 100 µg/ml. This solution can then be diluted into other aqueous buffers.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
USAGE For Research Use Only! Not to be used in humans

Details

The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the Activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kDa and type II receptors of about 70-80 kDa. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. BMPR1A Human Recombinant extracellular domain produced in baculovirus is a monomeric, glycosylated, polypeptide chain fused with 6xHis tag at C-terminus and having a molecular mass of 23 kDa. The BMR1A is purified by proprietary chromatographic techniques.


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