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BMP-6, human recombinant

based on 2 citations in multiple journalsBMP-6, human recombinant24.1 4
Induces all osteogenic markers in mesenchymal stem cells.
Catalog #: 4911
SKU-Size Size Price Qty
4911-10 10 μg
$180.00
4911-50 50 μg
$495.00
4911-1000 1 mg
$3,950.00
4911-10MG 10 mg
$19,950.00
More Sizes Get Quote

Product Details

Alternate Name VGR, VGR1, BMP-6, VG-1-related protein
Gene Symbol BMP6
Gene ID 654
Accession # P22004
Source E. coli
Appearance Lyophilized protein
Physical Form Description Sterile filtered and lyophilized with no additives
Molecular Weight monomer (15 kDa), dimer (30 kDa)
Purity by SDS-PAGE ≥98%
Purity by ≥98%
Endotoxin Level <0.1 ng/μg
Biological Activity BioVision’s recombinant human BMP-6 is biologically active. The ED₅₀ as determined by dose-dependent induction of alkaline phosphatase activity with C2C12 cells is in the range of 2-12 µg/ml.
Reconstitution Instructions Reconstitute to a concentration of 0.1-1.0 mg/ml in sterile 20 mM acetic acid. This solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or –20°C for future use.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

BMPs (bone morphogenetic proteins) belong to the TGF-β superfamily of structurally related signaling proteins. As implied by their name, BMPs promote and regulate bone development, growth, remodeling and repair, in both prenatal development and postnatal growth of eye, heart, kidney, skin, and other tissues. Recombinant human BMP-6 produced from E. coli contains a mixture of monomer (15 kDa), dimer (30 kDa), and multimers. The dimer is an active polypeptide chain containing 2X142 amino acid residues.


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Crews, L. et al. Increased BMP6 Levels in the Brains of Alzheimer's Disease Patients and APP Transgenic Mice Are Accompanied by Impaired Neurogenesis. J. Neurosci., Sep 2010; 30: 12252 - 12262.
Jukes JM et al (2008) PNAS 105: 6840-6845.
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