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BMP-2, human recombinant

based on 3 citations in multiple journalsBMP-2, human recombinant34.1 4
A protein involved in the hedgehog and TGF beta signaling pathway
Catalog #: 4577
SKU-Size Size Price Qty
4577-10 10 μg
$190.00
4577-50 50 μg
$550.00
4577-1000 1 mg
$4,565.00
More Sizes Get Quote

Product Details

Alternate Name BMP-2, BMP2A, bone morphogenetic protein2
Gene Symbol BMP 2
Gene ID 650
Accession # P12643
Source E. coli
Appearance Lyophilized protein
Physical Form Description Lyophilized without additives
Molecular Weight 26.0 kDa
Purity by SDS-PAGE ≥98%
Purity by ≥98%
Endotoxin Level <0.1 ng/μg
Biological Activity The ED₅₀ as determined by the dose-dependent cytolysis of MC3T3-E1 cells is < 50 ng/ml.
Reconstitution Instructions Reconstitute to a concentration of 0.1-1.0 mg/ml in H₂O containing BSA (50 ug BSA per 1 ug of protein). This solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or –20°C for future use.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

BMPs (bone morphogenetic proteins) belong to the TGF-β superfamily of structurally related signaling proteins. As implied by their name, BMPs promote and regulate bone development, growth, remodeling and repair, in both prenatal development and postnatal growth of eye, heart, kidney, skin, and other tissues. In addition to its osteogenic activity, BMP-2 also plays an important role in cardiac morphogenesis. BMP-2 is expressed in a variety of tissues such as lung, spleen, brain, liver, prostate ovary, and small intestine. Recombinant human BMP-2 is a 26 kDa homodimeric protein consisting of two 115 amino acid polypeptide chains


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Cheuk Wun Li, et. al. Spatiotemporal Expression of Bone Morphogenetic Protein Family Ligands and Receptors in the Zebrafish Ovary: A Potential Paracrine-Signaling Mechanism for Oocyte-Follicle Cell Communication. Biol Reprod, Nov 2011; 85: 977 - 986.
Itoh, T. et al. MicroRNA-208 Modulates BMP-2-stimulated Mouse Preosteoblast Differentiation by Directly Targeting V-ets Erythroblastosis Virus E26 Oncogene Homolog 1. J. Biol. Chem., Sep 2010; 285: 27745 - 27752.
Itoh T et al (2009) J. Biol. Chem.; 284: 19272 - 19279.
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