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BMP-14 (GDF-5/CDMP-1), human recombinant

A protein involved in bone and cartilage development
Catalog #: 4580
SKU-Size Size Price Qty
4580-10 10 μg
$85.00
4580-50 50 μg
$200.00
4580-1000 1 mg
$1,500.00
More Sizes Get Quote

Product Details

Alternate Name Cartilage-derived morphogenetic protein-1, CDMP-1, LAP4, SYNS2, GDF-5, Radotermin, CDMP1, GDF5, Growth differentiation factor 5, BMP-14
Gene Symbol GDF5
Gene ID 8200
Accession # P43026
Source E. coli
Appearance Lyophilized protein
Physical Form Description Sterile filtered and lyophilized from 10 mM Sodium Citrate, pH 3.5.
Molecular Weight 13.6 kDa
Purity by SDS-PAGE ≥98%
Purity by ≥98%
Endotoxin Level <0.1 ng/μg
Biological Activity The ED₅₀ as determined by its ability to induce alkaline phosphatase production by ATDC-5 chondrogenic cells is 1-2 µg/ml.
Reconstitution Instructions Reconstitute to a concentration of 0.1-1.0 mg/ml in H₂O containing BSA (50 mg BSA per 1 mg of protein). This solution can then be diluted into other aqueous buffers.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
USAGE For Research Use Only! Not to be used in humans

Details

BMPs (bone morphogenetic proteins) belong to the TGF-β superfamily of structurally related signaling proteins. As implied by their name, BMPs promote and regulate bone development, growth, remodeling and repair, in both prenatal development and postnatal growth of eye, heart, kidney, skin, and other tissues. In addition to its osteogenic activity, BMP-14 is a principal inhibitor of cartilage development and is predominantly expressed in long bone during human embryonic development. Recombinant human BMP-14 is a 27 kDa homodimeric protein consisting of two 120 amino acid polypeptide chains.


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Huibin Tang, mTORC1 underlies age‐related muscle fiber damage and loss by inducing oxidative stress and catabolism. Aging Cel, March 2019; 30924297.
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