Product Details
| abID | ab52315 |
|---|---|
| Alternate Name | Cartilage-derived morphogenetic protein-1, CDMP-1, LAP4, SYNS2, GDF-5, Radotermin, CDMP1, GDF5, Growth differentiation factor 5, BMP-14 |
| Gene Symbol | GDF5 |
| Gene ID | 8200 |
| Accession # | P43026 |
| Source | E. coli |
| Appearance | Lyophilized protein |
| Physical Form Description | Lyophilized without additives |
| Molecular Weight | 13.6 kDa |
| Purity by SDS-PAGE | ≥98% |
| Biological Activity | The EC50 as determined by its ability to induce alkaline phosphatase production by ATDC-5 chondrogenic cells is 1-10 µg/ml. |
| Reconstitution Instructions | Reconstitute to a concentration of 0.1-1.0 mg/ml in H₂O containing BSA (50 mg BSA per 1 mg of protein). This solution can then be diluted into other aqueous buffers. |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -20°C |
| USAGE | For Research Use Only! Not to be used in humans |
Details
BMPs (bone morphogenetic proteins) belong to the TGF-β superfamily of structurally related signaling proteins. As implied by their name, BMPs promote and regulate bone development, growth, remodeling and repair, in both prenatal development and postnatal growth of eye, heart, kidney, skin, and other tissues. In addition to its osteogenic activity, BMP-14 is a principal inhibitor of cartilage development and is predominantly expressed in long bone during human embryonic development. Recombinant human BMP-14 is a 27 kDa homodimeric protein consisting of two 120 amino acid polypeptide chains.
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Huibin Tang, mTORC1 underlies age‐related muscle fiber damage and loss by inducing oxidative stress and catabolism. Aging Cel, March 2019; 30924297.
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