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BMP-12/GDF-7, human recombinant

A protein with functions in regulating inflammatory and apoptotic pathways
Catalog #: 4572
SKU-Size Size Price Qty
4572-20 20 μg
$210.00
4572-100 100 μg
$520.00
4572-1000 1 mg
$3,835.00
More Sizes Get Quote

Product Details

Alternate Name BMP-12/GDF-7, BMP12/GDF7, BMP 12/GDF 7,
Gene Symbol BMP12/GDF7
Gene ID 151449
Accession # BAD07014
Source E. coli
Appearance Lyophilized protein
Physical Form Description Sterile filtered and lyophilized with no additives
Molecular Weight 27 kDa
Purity by SDS-PAGE ≥98%
Purity by ≥98%
Endotoxin Level <0.1 ng/μg
Biological Activity The protein is biologically active as determined by its ability to induce alkaline phosphatase production by ADTC5 mouse chondrogenic cells. The ED₅₀ for this effect is typically 0.2 – 2.5 µg/ml.
Reconstitution Instructions Reconstitute to a concentration of 0.1-1.0 mg/ml in H₂O containing BSA (50 µg BSA per 1 µg of protein). This solution can then be diluted into other aqueous buffers.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
USAGE For Research Use Only! Not to be used in humans

Details

BMPs (bone morphogenetic proteins) belong to the TGF-β superfamily of structurally related signaling proteins. As implied by their name, BMPs promote and regulate bone development, growth, remodeling and repair, in both prenatal development and postnatal growth of eye, heart, kidney, skin, and other tissues. BMP-12 is highly conserved across species. BMP-12 regulates chondrogenesis, bone morphogenesis, and neuron differentiation. Recombinant human BMP-12 is a 27 kDa disulfide-linked homodimer containing two 122 amino acid polypeptide chains.


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