Product Details
| abID | ab285594 |
|---|---|
| Alternate Name | bone morphogenetic protein 11, BMP11, BMP 11, Growth/Differentiation Factor-11, GDF-11, GDF11, GDF 11 |
| Gene Symbol | BMP11/GDF11 |
| Gene ID | 10220 |
| Accession # | O95390 |
| Source | E. coli |
| Appearance | Lyophilized protein |
| Physical Form Description | Lyophilized from 10 mM Sodium Citrate, pH 3.5. |
| Molecular Weight | 32.6 kDa |
| Purity by SDS-PAGE | ≥98% |
| Purity by | ≥98% |
| Endotoxin Level | <0.1 ng/μg |
| Biological Activity | The protein is biologically active as determined by its ability to induce alkaline phosphatase production by C2C12 cells. The ED₅₀ is in the range of 0.4-4 µg/ml. |
| Reconstitution Instructions | Reconstitute to a concentration of 0.1-1.0 mg/ml in H₂O containing BSA (50 μg BSA per 1 μg of protein). This solution can then be diluted into other aqueous buffers. |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -20°C |
| USAGE | For Research Use Only! Not to be used in humans |
Details
BMPs (bone morphogenetic proteins) belong to the TGF-β superfamily of structurally related signaling proteins. As implied by their name, BMPs promote and regulate bone development, growth, remodeling and repair, in both prenatal development and postnatal growth of eye, heart, kidney, skin, and other tissues. Recombinant human BMP-11 is N-terminus His-tagged protein with a molecular weight of 32.6 kDa (for homodimeric) and 16.2 (for monomeric) consisting of 136 amino acid polypeptide chains.
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