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BML-284

A potent and selective activator of Wnt signaling
Catalog #: B1077
SKU-Size Size Price Qty
B1077-10 10 mg
$125.00
B1077-50 50 mg
$485.00
More Sizes Get Quote

Product Details

Alternate Name 2-Amino-4-[3,4-(methylenedioxy)benzylamino]-6-(3-methoxyphenyl)pyrimidine
Appearance Off-white solid
CAS # 853220-52-7
Molecular Formula C₁₉H₁₈N₄O₃
Molecular Weight 350.37
Purity ≥98% by HPLC
Solubility DMSO (>25 mg/ml)
SMILES COC1=CC=CC(=C1)C2=CC(=NC(=N2)N)NCC3=CC4=C(C=C3)OCO4
InChi InChI=1S/C19H18N4O3/c1-24-14-4-2-3-13(8-14)15-9-18(23-19(20)22-15)21-10-12-5-6-16-17(7-12)26-11-25-16/h2-9H,10-11H2,1H3,(H3,20,21,22,23)
InChi Key FABQUVYDAXWUQP-UHFFFAOYSA-N
PubChem CID 11210285
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

BML-284 is cell-permeable Wnt signaling pathway agonist. It mimics the effects of a Wnt ligand in a Xenopus model and may be a useful tool in the study of physiological processes that involve the Wnt signaling pathway due to activation of Wnt without inhibiting the activity of GSK-3β; it induces in vitro β-catenin and transcription factor (TCF) dependent transcriptional activity in 293T cells in a dose-dependent manner with an EC₅₀ of 700 nM.


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