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BLU-667 (Pralsetinib)

A highly potent, selective, next generation RET inhibitor
Catalog #: B2548
SKU-Size Size Price Qty
B2548-1 1 mg
$85.00
B2548-5 5 mg
$335.00
More Sizes Get Quote

Product Details

Alternate Name Pralsetinib free base, cis-N-{(1S)-1-[6-(4-fluoro-1H-pyrazol-1-yl)pyridin-3-yl]ethyl}-1-methoxy-4-{4-methyl-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl}cyclohexane-1-carboxamide, BLU 667, BLU667
Peptide Sequence N/A
Appearance Crystalline solid
CAS # 2097132-94-8
Molecular Formula C₂₇H₃₂FN₉O₂
Molecular Weight 533.6
Purity ≥98% by HPLC
Solubility >50 mg/ml in DMSO
SMILES CC1=CC(=NN1)NC2=NC(=NC(=C2)C)C3CCC(CC3)(C(=O)NC(C)C4=CN=C(C=C4)N5C=C(C=N5)F)OC
InChi InChI=1S/C27H32FN9O2/c1-16-11-22(33-23-12-17(2)35-36-23)34-25(31-16)19-7-9-27(39-4,10-8-19)26(38)32-18(3)20-5-6-24(29-13-20)37-15-21(28) 14-30-37/h5-6,11-15,18-19H,7-10H2,1-4H3,(H,32,38)(H2,31,33,34,35,36)/t18-,19?,27?/m0/s1
InChi Key GBLBJPZSROAGMF-SIYOEGHHSA-N
PubChem CID 129073603
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

BLU-667 (Pralsetinib) is a highly potent and selective, next generation RET inhibitor with IC₅₀ of 0.3-0.4 nM for WT RET, RET mutants V804L, V804M, M918T and CCDC6-RET fusion. In vivo, BLU-667 potently inhibits growth of NSCLC and thyroid cancer xenografts driven by various RET mutations and fusions without inhibiting VEGFR2.


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